• UK Pharmacogenetics & Stratified Medicine Network

    We are dedicated to developing collaborative partnerships
    between healthcare professionals, academic researchers,
    industry partners, regulatory bodies and patients
    to synergise research into stratified medicine across the UK
    and support its adoption into the clinic.


What is Pharmacogenetics?

Pharmacogenetics is the study of inherited genetic differences in drug metabolic pathways which can affect an individual’s response to drugs. These genetic differences may result in a positive response to a drug therapy or may cause an adverse drug reaction.
Pharmacogenomics is the study of how genes affect a person’s response to drugs, combining pharmacology (the science of drugs) and genomics (the study of genes and their functions) to develop effective, safe medications with dosing tailored to a person’s genetic makeup. Pharmacogenetics plays an important role in offering a stratified medicine approach to improve patient care.

What is Stratified Medicine?

Stratified medicine (also described as personalised, precision, or P4 Predictive, Preventive, Personalized and Participatory medicine) uses technical advances in genetic sequencing techniques, and bespoke diagnostic tests, to prescribe the drug that is most likely to have a positive therapeutic effect, at the optimum dose and in the right combination with other medication, to patients at the start of their treatment. Thus patients have their treatment based on their genetic profile, molecular basis of their disease, risk of disease, or response to a particular drug therapy, rather than the signs or symptoms of their disease.

Traditionally patients have been prescribed their medication based on the signs and symptoms of their disease.  If a treatment is not successful patients have to be prescribed an alternative medication.

Academic and clinical research has revealed that most diseases have multiple subtypes that require different treatment approaches. Pharmacogenetic data and bespoke diagnostic tests enable clinicians to identify the subcategory of disease and offer patients the most effective treatments from the outset of their treatment. 


Contact Us

University of Liverpool

Block A: Waterhouse Buildings

1-5 Brownlow Street

Liverpool L69 3GL

Email: nelsdon@liverpool.ac.uk


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